Endocrine Abstracts

Introduction: Mitochondrial uncoupling proteins (UCPs) are transmembrane channels present in the inner mitochondrial membrane whose function is the transport of protons and small substrates between the intermembrane space and the mitochondrial matrix. UCPs are key regulators of cellular metabolism, including mitochondrial function, oxidative phosphorylation, and reactive oxygen species (ROS) production. UCPs’ dysfunction has been associated with the onset of metabolic dis...

Introduction: Mitochondrial uncoupling proteins (UCPs) are channel proteins present in the mitochondrial inner membrane which are responsible for the transport of protons between the mitochondrial intermembrane space and the matrix. Currently, six UCP homologues had been identified (UCP1-6). UCPs are major regulators of reactive oxygen species (ROS) production, general cellular redox state and metabolism. UCPs also exhibit specific functions, such as UCP1 and thermogenesis or ...

Introduction: Atrazine is one of the most widely used pesticides worldwide and a common contaminant in human drinking water. Atrazine is also a potent endocrine disruptor capable of causing a variety of negative health outcomes, including decreased testosterone production and infertility. Although harmful effects of atrazine on male reproductive health have been reported, little is known about its molecular mechanisms. Within the seminiferous tubules, Sertoli cells are respons...